Behavioural Intervention
DASH Diet for Kidney Stones
This trial aims to determine the effect of following a healthy diet on the risk of kidney stones. The researchers will test the hypothesis that a DASH-style diet can improve certain factors related to kidney stone risk
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Trials for Kidney Stones Patients
Thiazolidinedione
Pioglitazone + Weight Loss for Kidney Stones
This trial tests the effects of Pioglitazone, weight loss, or both in overweight and obese patients with uric acid kidney stones. Pioglitazone helps the body use insulin better and reduces urine acid, while weight loss improves health and reduces the risk of stones.
Antibiotic
Antibiotic Prophylaxis for Kidney Stones
This trial is testing whether using a single dose of ciprofloxacin before Shock Wave Lithotripsy (SWL) is better than using saline alone. The trial will be conducted with a pragmatic emphasis including both high volume and low volume sites internationally.
Trials for Kidney Stones Patients
Antibiotic
Antibiotic Prophylaxis for Kidney Stones
This trial is testing whether using a single dose of ciprofloxacin before Shock Wave Lithotripsy (SWL) is better than using saline alone. The trial will be conducted with a pragmatic emphasis including both high volume and low volume sites internationally.
Ultrasound
Ultrasonic Stone Propulsion for Kidney Stones
This trial tests using sound waves to move kidney stones in patients who have leftover fragments after treatment. The goal is to help these stones pass naturally, reducing pain and the need for further treatments. Focused ultrasound has been developed and tested for relocating and expelling kidney stones.
Dietary Modification
Prevention Strategies for Kidney Stones
This trial compares two methods to prevent kidney stones in patients who have had multiple episodes. One method uses specific urine tests to guide treatment, while the other uses a general treatment approach. Both methods involve diet changes and medications to reduce stone-forming substances in the urine. Recognized medications for preventing kidney stone recurrence include thiazide diuretics, allopurinol, and potassium citrate.
Trials With No Placebo
Thiazolidinedione
Pioglitazone + Weight Loss for Kidney Stones
This trial tests the effects of Pioglitazone, weight loss, or both in overweight and obese patients with uric acid kidney stones. Pioglitazone helps the body use insulin better and reduces urine acid, while weight loss improves health and reduces the risk of stones.
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Frequently Asked Questions
Introduction to kidney stone
What are the top hospitals conducting kidney stone research?
When it comes to pioneering clinical trials in the realm of kidney stones, several esteemed hospitals have emerged as leaders in the field. One such institution is the University of Alabama at Birmingham (UAB) located in the vibrant city of Birmingham. UAB currently has nine active clinical trials centered around kidney stones, and although its all-time count stands at just nine trials, this hospital has been making significant strides since recording its first trial focusing on kidney stones back in 2013.
In Nashville, Tennessee, Vanderbilt University Medical Center is another prominent player in advancing our understanding of kidney stone treatments. With four ongoing clinical trials dedicated to investigating new ways to combat this condition and a total of seven completed studies throughout their medical history, Vanderbilt's commitment to finding innovative solutions began with their inaugural trial on kidney stones in 2009.
On the picturesque West Coast lies San Francisco’s University of California campus that houses the renowned UCSF Medical Center - a facility known for groundbreaking research across various fields. In relation to kidney stones specifically, UCSF is actively engaged in three clinical trials aimed at discovering novel approaches for treatment. Since conducting their first recorded trial centered around these mineral formations in 2014 and completing six overall investigations so far, UCSF continues to be an influential voice shaping future practices surrounding this common ailment.
Further eastward towards Cleveland Ohio stands the prestigious Cleveland Clinic Foundation – recognized internationally for its cutting-edge healthcare initiatives. This institution also plays a crucial role when it comes to advancements related to kidney stone treatment through three currently ongoing clinical trials. Having started their journey by initiating their inaugural investigation focused on these troublesome formations just five years ago, precisely in 2015; they now boast four completed studies contributing significantly toward enhancing patient outcomes.
Lastly but not leastly situated along California’s stunning coastline rests the University of California San Diego (UCSD). As part of UCSD Health's dedication toward providing optimal care options for patients suffering from kidney stone-related issues, they are actively conducting three clinical trials in this area. Since embarking on their first kidney stone trial in 2016, UCSD has already amassed a total of four completed studies and continues to explore innovative ways to alleviate the burden of kidney stones.
Through the tireless efforts of these leading hospitals and research institutions across the country, our understanding of kidney stones is continually expanding. With each new clinical trial, we inch closer toward more effective treatments that can relieve the pain and discomfort caused by these stubborn mineral formations.
Which are the best cities for kidney stone clinical trials?
In the realm of kidney stone clinical trials, several cities emerge as key players in advancing research and treatment options. Birmingham, Alabama leads the pack with 9 active trials exploring interventions like Low Oxalate Diet, Controlled Diet, and examining Type 2 diabetic kidney stone formers. Vancouver, British Columbia follows closely behind with 7 ongoing studies focused on medications such as ciprofloxacin, cotrimoxazole-trimethoprim, macrodantin along with procedures like Standard Percutaneous Nephrolithotomy (sPCNL). Chicago, Illinois also boasts 7 active trials investigating dietary modifications and innovative technologies like Storz Flex-XC1 disposable flexible ureteroscope. Through their contributions to research efforts in this field are San Diego California with its emphasis on different treatment approaches including Ureteral stent group and Cleveland Ohio which focuses on devices such as Storz Modulith SLX-F2 for treatment. These cities provide valuable platforms for individuals seeking participation in groundbreaking clinical trials that have the potential to improve outcomes for those affected by kidney stones.
Which are the top treatments for kidney stone being explored in clinical trials?
Exciting developments are occurring in the field of kidney stone treatments, with several promising options currently being explored through clinical trials. A low oxalate diet is taking center stage, with three active trials and four all-time kidney stone trials since its listing in 2021. Potassium citrate is also showing potential, undergoing two ongoing trials and having a total of two kidney stone trials to date since its introduction in 2021. Additionally, ambulatory tubeless PCNL has emerged as a new contender, currently involved in one active trial and marking its first appearance on the scene in 2022. These innovative approaches hold promise for improving outcomes for individuals suffering from kidney stones.
What are the most recent clinical trials for kidney stone?
Recent clinical trials have brought forth promising developments in the field of kidney stone treatment. One such study focuses on the use of NSAIDs, which has entered Phase 4 and became available on 5/19/2023. Additionally, an Erector Spinae Plane Block (ESPB) trial for kidney stones is underway after reaching Phase 2 with availability from 2/8/2023. Selective Therapy involving a specific drug also shows potential and is currently in Phase 4 since becoming available on 8/4/2022. Moreover, Pregabalin at a dosage of 300mg has progressed through Phases 2 and Phase 3, first becoming available on6 /1 /2020. Lastly, research exploring weight loss as a means to address kidney stones reached Phase 4 availability starting from10 /17 /2019. These advancements offer hope for improved treatments for those affected by kidney stones.
What kidney stone clinical trials were recently completed?
One notable clinical trial in the field of kidney stones recently reached completion, shedding light on potential new treatments for this common condition. In July 2018, Montefiore Medical Center concluded a trial investigating the efficacy of Acetaminophen. This study provides valuable insights into the use of this medication and contributes to our understanding of how to manage kidney stone-related pain. While further research is needed, these results offer hope for individuals suffering from this painful ailment and pave the way for future advancements in kidney stone treatment options.