What side effects are associated with this type of intervention?

Beet-root juice supplementation is generally well-tolerated, but some individuals may experience gastrointestinal discomfort, including bloating, gas, and diarrhea. Additionally, beet-root juice can cause beeturia, a harmless condition where urine turns pink or red. Red light therapy is also considered safe with minimal side effects, but some users may experience temporary redness, tightness, or irritation of the skin. Both treatments are non-invasive and have a low risk of serious adverse effects.

What prior FDA approvals exist?

There are no specific FDA-approved treatments directly targeting Health Care Utilization that are similar to beet-root juice supplementation or red light therapy. However, treatments that enhance nitric oxide production, such as certain cardiovascular drugs, and therapies that use photobiomodulation, like low-level laser therapy for pain management, have been approved for other health conditions. These treatments indirectly contribute to improved health outcomes, which can potentially reduce overall health care utilization.

What other types of research exist?

Promising alternatives to beet-root juice supplementation and red light therapy include: 1) Black tea consumption, which may increase cerebral blood flow and improve vascular function. 2) Cinnamon supplementation, which has shown potential in lowering fasting blood glucose levels and may have vascular benefits. 3) Resveratrol, an antioxidant found in red wine and certain fruits, which has been studied for its potential benefits in vascular health and cellular function. 4) Photodynamic therapy with hypericin, which has shown efficacy in stimulating cellular function and treating certain cancers. 5) The DASH diet, which has been associated with improved vascular health and reduced risk of conditions like gout.

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Beet-root Juice + Red Light Therapy for Muscle Fatigue

N/A

Recruiting

Led By Andrew D Wells, Ph.D.

Research Sponsored by Wake Forest University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during the forearm exercise fatigue protocol lasting up to 45 minutes

Summary

This trial is testing whether drinking beet-root juice and using red light therapy can help older adults over 65 improve their forearm muscle endurance. Beet-root juice may boost blood flow to muscles, while red light therapy might help muscles work better and recover quicker. The study will compare these treatments alone and together. Beetroot juice has been shown to have antioxidant, anti-inflammatory, and vasodilatory effects, which may improve blood flow and muscle recovery.

Who is the study for?

This trial is for healthy older adults over 65 who exercise lightly to moderately at least three times a week. It's not for those with liver or kidney disease, recent smokers, people with joint pain in the dominant hand, gastritis, thyroid conditions, or those on medications that interact with nitrates.

What is being tested?

The study tests if beet-root juice and red light therapy can help forearm muscles last longer without getting tired. Older adults will try these treatments separately and together against placebo (fake treatment) and sham light to see which helps muscle endurance more.

What are the potential side effects?

Beet-root juice might cause stomach issues or turn urine pink but is generally safe. Red-light therapy could lead to eye strain if not used properly. Placebos and sham lights have no active components so they should not cause any direct side effects.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during the forearm exercise fatigue protocol lasting up to 45 minutes

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during the forearm exercise fatigue protocol lasting up to 45 minutes

This trial's timeline: 3 weeks for screening, Varies for treatment, and during the forearm exercise fatigue protocol lasting up to 45 minutes for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Total forearm work performed

Secondary study objectives

Forearm

Intermuscular coordination

Trial Design

4Treatment groups

Experimental Treatment

Active Control

Placebo Group

Group I: Beet-root juice plus red-light therapyExperimental Treatment2 Interventions

Group II: Placebo plus sham light therapyActive Control2 Interventions

Group III: Beet-root juice plus sham light therapyPlacebo Group2 Interventions

Group IV: Placebo plus red-light therapyPlacebo Group2 Interventions

Do I qualify?Apply below to find out

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for Health Care Utilization, such as beet-root juice supplementation and red light therapy, work through distinct mechanisms. Beet-root juice enhances nitric oxide production, which improves blood flow and muscle function. Red light therapy stimulates cellular function and energy production through photobiomodulation. These mechanisms are important for Health Care Utilization patients as they can lead to improved physical performance, reduced muscle fatigue, and better overall vascular health, potentially decreasing the need for medical interventions.

Scavenging activity of "beta catechin" on reactive oxygen species generated by photosensitization of riboflavin.Effects of Baru Almond Oil (Dipteryx alata Vog.) Treatment on Thrombotic Processes, Platelet Aggregation, and Vascular Function in Aorta Arteries.Acute Beetroot Juice Supplementation Does Not Improve Match-Play Activity in Professional Tennis Players.