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Exercise Training for Heart Failure

N/A

Waitlist Available

Research Sponsored by University of Texas Southwestern Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

All subjects will be >65 years of age

Patients for HFpEF must be > 65 years old

Must not have

Patients on Coumadin

Chronic lung disease

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change in reactive hyperemia after 8 weeks of exercise training

Awards & highlights

No Placebo-Only Group

Summary

This trial will investigate whether targeting peripheral skeletal muscle deficiencies can improve aerobic capacity and exercise tolerance in HFpEF patients.

Who is the study for?

This trial is for people over 65 with heart failure where the heart pumps normally but fills abnormally (HFpEF). They must show signs of heart failure, have a normal ejection fraction (>0.50), and evidence of diastolic dysfunction. Excluded are those with severe lung or advanced heart diseases, certain arrhythmias, heavy exercise habits, recent smokers, kidney issues, or on specific heart medications.

What is being tested?

The study tests if exercising one leg can improve blood flow to muscles, muscle oxygen use during exercise, and reduce nerve activity that narrows blood vessels in patients with HFpEF. It involves an 8-week knee extensor training program to see if these exercises can enhance overall exercise capacity and oxygen uptake.

What are the potential side effects?

Since the intervention is exercise training focused on one leg's muscles (knee extensors), side effects may include muscle soreness or fatigue post-exercise. However, as it's non-drug therapy for elderly individuals with specific health conditions, risks will be closely monitored.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am older than 65 years.

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I am over 65 years old and have heart failure with preserved ejection fraction.

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I have heart failure with preserved ejection fraction as per European Guidelines.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am taking Coumadin.

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I have a long-term lung condition.

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I have been diagnosed with acute myocarditis.

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My heart failure is severe and not controlled by medication.

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I have a heart valve condition.

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I have heart disease caused by reduced blood flow to my heart.

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I have atrial flutter or fibrillation.

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I have a heart condition present from birth or a valve problem.

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My kidneys do not work properly.

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I have a heart condition that affects how my heart fills with blood.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change in exercise hyperemia after 8 weeks of exercise training

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change in exercise hyperemia after 8 weeks of exercise training

This trial's timeline: 3 weeks for screening, Varies for treatment, and change in exercise hyperemia after 8 weeks of exercise training for reporting.