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Behavioral Intervention

Cognitive Rehabilitation for Hoarding Disorder (CREST Trial)

N/A

Recruiting

Led By Catherine R Ayers, PhD

Research Sponsored by VA Office of Research and Development

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Veterans age 18 and older

Be older than 18 years old

Must not have

current or history of any neurodegenerative disease

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 1.5 months, 3 months, and 9 months

Awards & highlights

No Placebo-Only Group

Summary

This trial will study whether a personalized, shorter treatment plan for Hoarding Disorder (HD) is more effective than case management in improving symptoms and quality of life for Veterans.

Who is the study for?

This trial is for adult Veterans diagnosed with Hoarding Disorder (HD) as their primary condition. Participants must be stable on medications for at least six weeks, voluntarily consent to join, and not have any neurodegenerative diseases or current psychosis. They should also not be undergoing any exposure-based psychotherapy.

What is being tested?

The study tests a personalized Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST), delivered via telemedicine and home visits over 24 sessions, against standard case management. The aim is to improve function and quality of life in Veterans with HD.

What are the potential side effects?

While the trial does not involve medication that typically has side effects, participants may experience emotional discomfort during therapy sessions due to confronting hoarding behavior.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am a veteran aged 18 or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have never had a disease that causes the loss of brain function.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 1.5 months, 3 months, and 9 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 1.5 months, 3 months, and 9 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 1.5 months, 3 months, and 9 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Activities of Daily Living in Hoarding Scale Change

PROMIS-43 Profile v2.1 Change

Quality of Life in Neurological Disorders (Neuro-QoL) Positive Affect and Well-Being Short form Change

+1 more

Secondary study objectives

Clutter Image Rating Scale (CIR) Change

Savings Inventory-Revised (SI-R) Change

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: CRESTExperimental Treatment1 Intervention

Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) provides training in compensatory cognitive strategies to address the executive dysfunction typical of individuals with HD, then helps reduce the distress associated with discarding items via exposure therapy.

Group II: Case ManagementActive Control1 Intervention

Case Management (CM). CM is the most widely available and utilized intervention for HD and is considered standard of care. This form of treatment involves managing the functional, housing, and legal ramifications of HD. Additionally, CM often involves assistance with economic, health, and social resources while providing support for the client.

0 / 2Eligibility criteria met