Grafting Materials for Misaligned Teeth

N/A

Waitlist Available

Led By Sahar Dowlatshahi, DDS, MMSc

Research Sponsored by The University of Texas Health Science Center, Houston

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

American Society of Anesthesiologists (ASA) I/II

No history of periodontitis

Must not have

Excessive retroclined mandibular incisors

Uncontrolled diabetes or other metabolic systemic conditions

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, at alignment (approximately 4 months after the start of orthodontics treatment).

Awards & highlights

No Placebo-Only Group

Summary

"This trial aims to study the effects of two different treatments on the bones and gums around the front teeth in the lower jaw. One group will receive a specific type of treatment with freeze-dried bone graft

Who is the study for?

This trial is for individuals with misaligned teeth or malocclusion. Participants should be suitable candidates for orthodontic therapy and willing to undergo surgical procedures as part of their treatment.

What is being tested?

The study tests the effects of surgically facilitated orthodontics therapy (SFOT) using two different graft materials: freeze-dried allograft and particulate xenograft, each paired with a collagen membrane, compared to usual care without SFOT.

What are the potential side effects?

Potential side effects may include discomfort at the surgery site, swelling, bruising, bleeding gums, infection risk at the grafting area, and possible allergic reactions to graft materials.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am in good or mild systemic disease state according to ASA standards.

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I have never had gum disease.

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My orthodontic plan does not include tooth removal.

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I have a skin area that's at least 3mm thick.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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My lower front teeth lean too far backward.

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I do not have uncontrolled diabetes or other unmanaged health conditions.

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I have an open bite or deep bite.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, at alignment (approximately 4 months after the start of orthodontics treatment).

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, at alignment (approximately 4 months after the start of orthodontics treatment).

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, at alignment (approximately 4 months after the start of orthodontics treatment). for reporting.