Knee Artery Embolization for Osteoarthritis

Palo Alto (17 mi)

Overseen byAndre Uflacker, MD

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: N/A

Recruiting

Sponsor: Medical University of South Carolina

No Placebo Group

Trial Summary

What is the purpose of this trial?The objective of this study is to investigate if MRI can be used to evaluated effect of knee artery embolization for knee osteoarthritis. Participants be evaluated in clinic, obtain a knee MRI, undergo embolization of the symptomatic knee, and follow up in clinic at 1, 6, and 12 months after embolization. A second MRI is obtained 6 months after embolization. Participants will keep a record of their pain level and treatment and answer questionnaires at each visit. In addition, this study aims to determine the effects of knee artery embolization on the amount of opioid (pain reliever drugs) needed to manage osteoarthritis-associated pain and change in quality of life.

Eligibility Criteria

This trial is for adults aged 25-90 with knee osteoarthritis, who've tried non-surgical pain treatments like injections or NSAIDs. They must be able to consent and have no MRI contraindications, severe kidney issues, malignancy in the knee, rheumatoid arthritis/gout, recent septic arthritis, or past major knee surgery.

Inclusion Criteria

I have knee pain due to arthritis, confirmed by an X-ray.

I can safely undergo MRI scans with contrast.

I can understand and agree to the study's terms on my own.

I am between 25 and 90 years old.

Exclusion Criteria

I have Rheumatoid Arthritis or Gout.

I have bleeding within my joints.

My knee cancer is confirmed.

I have had knee surgery before.

My kidney function is low, with a GFR under 30ml/min.

I am not pregnant nor planning to become pregnant during the study.

I have severe artery disease in my legs that prevents certain artery procedures.

Treatment Details

The study tests if geniculate artery embolization reduces pain from knee osteoarthritis and improves quality of life. It involves initial/follow-up clinic visits, two MRIs (one before and one six months after treatment), and participants tracking their pain levels.

1Treatment groups

Experimental Treatment

Group I: GAE and MRI treatment armExperimental Treatment2 Interventions

GAE is geniculate artery embolization.