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Prophylactic Uterosacral Ligament Suspension at the Time of Hysterectomy for Prevention of Vaginal Vault Prolapse

N/A
Waitlist Available
Led By Marianna Alperin, MD
Research Sponsored by Kaiser Permanente
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

Is routine uterosacral ligament suspension an appropriate clinical adjunct at the time of hysterectomy? The answers to these questions will facilitate the treatment of many American women. With the results of this study, the investigators would anticipate a reduction in the number of surgeries for pelvic organ prolapse. In addition, if uterosacral ligament suspension was shown to be ineffective, it would not be used routinely in the setting of hysterectomy and women will be spared the additional procedure and possibility of side effects or complications. The relative risks and benefits of adding a prophylactic uterosacral ligament suspension at the time of hysterectomy in women without symptomatic prolapse symptoms have never been studied prospectively.

Eligible Conditions
  • Vaginal Vault Prolapse

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: uterosacral ligament suspensionExperimental Treatment1 Intervention
uterosacral ligament suspension colpopexy sutures will be placed bilaterally at the time of hysterectomy
Group II: hysterectomy aloneActive Control1 Intervention

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalOTHER
3,025 Previous Clinical Trials
13,413,068 Total Patients Enrolled
Kaiser PermanenteLead Sponsor
555 Previous Clinical Trials
27,731,417 Total Patients Enrolled
Marianna Alperin, MDPrincipal InvestigatorKaiser Permanente
~56 spots leftby Dec 2025