Trials in Boston, Massachusetts
Here are the top 10 medical studies for depression in Boston, Massachusetts
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Phase 3 Trials
Psychedelic
Psilocybin for Treatment-Resistant Depression
Recruiting1 awardPhase 3
North Worcester, Massachusetts
This trial is testing a new medication called COMP360 to help people with severe depression that hasn't improved with other treatments. The study involves adults aged 18 and older. Researchers want to see if a single dose of COMP360 can reduce depression symptoms when given with psychological support.
NMRA-335140 for Depression
Recruiting2 awardsPhase 3
Boston, Massachusetts
This trial is testing a new medication called NMRA-335140 to see if it helps people with major depressive disorder. It includes participants who have no safety concerns. The medication aims to improve mood by affecting brain chemicals.
Behavioural Intervention
NMRA 335140 for Depression
Recruiting1 awardPhase 3
Boston, Massachusetts
This trial is testing a new medication called NMRA 335140 to see if it can help people with Major Depressive Disorder feel less depressed. The study involves an initial evaluation and a treatment phase where participants will receive either the medication or an inactive substance. The medication likely works by changing brain chemicals that affect mood.
Lumateperone for Major Depressive Disorder
Recruiting1 awardPhase 3
Methuen, Massachusetts
This trial is testing lumateperone, a medication that may help people with depression who haven't improved with other treatments. The study includes patients diagnosed with Major Depressive Disorder who haven't responded well to their current antidepressants. Lumateperone works by balancing brain chemicals that affect mood, potentially improving depressive symptoms.
Trials With No Placebo
Behavioral Intervention
Cognitive Behavioral Therapy for COPD and Emotional Distress
Recruiting1 award
Boston, Massachusetts
This trial will test a new physical and mental health intervention for Veterans with COPD, emotional distress, and low physical activity. The intervention will be delivered via VA Video Connect.
Behavioral Intervention
Computer-Based Intervention for Depression
Recruiting1 award17 criteria
Belmont, Massachusetts
This trial will study how stress affects the brain's ability to process information related to perceived control among female adolescents with major depressive disorder, as well as how this may be linked to anhedonia (loss of pleasure) and maladaptive coping mechanisms.
Behavioral Intervention
FIRST Psychotherapy for Youth Mental Health Issues
Recruiting1 award3 criteria
Cambridge, Massachusetts
This trial will compare the effectiveness of a new transdiagnostic treatment against usual care outpatient psychotherapy, for youths' mental health outcomes. The new treatment is based on five principles of change, and one proposed mechanism of change is regulation of negative emotions.
Behavioural Intervention
Buspirone + Melatonin for Depression After Traumatic Brain Injury
Recruiting3 awardsPhase 4
Charlestown, Massachusetts
This trial is investigating the effectiveness of a novel treatment combination of Buspirone and Melatonin (B+MEL) in outpatients with clinical depression who have also suffered a traumatic brain injury (TBI). The trial will measure changes in depressive symptoms, cognitive symptoms, and brain activity before and after treatment.
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.