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What is Buprenex
BuprenorphineThe Generic name of this drug
Treatment SummaryBuprenorphine is a weak opioid used to treat severe pain and opioid addiction. It comes in the form of Suboxone, which is a combination of buprenorphine and naloxone. Naloxone prevents the opioid effects of buprenorphine if injected intravenously. Buprenorphine creates a long-lasting effect, providing relief for up to 24-36 hours. It also has a lower risk of overdose compared to other opioids like methadone, fewer drug interactions, and less Qtc interval prolongation. Buprenorphine is often used as part of Opioid
Buprenexis the brand name
Buprenex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Buprenex
Buprenorphine
1985
261
Approved as Treatment by the FDA
Buprenorphine, commonly known as Buprenex, is approved by the FDA for 2 uses which include Opioid Dependence and Opioid-Related Disorders .Opioid Dependence
Used to treat Opioid Dependence in combination with Naloxone
Opioid-Related Disorders
Used to treat Opioid Dependence in combination with Naloxone
Effectiveness
How Buprenex Affects PatientsBuprenorphine is an opioid used to treat pain. It works by interacting with opioid receptors in the brain, spinal cord, and other tissues. It causes pain relief, sedation, and can cause people to feel good or bad. It slows breathing, suppresses coughs, and makes pupils smaller. If taken for more than a month, it may cause dependence and withdrawal signs if stopped. It can also cause nausea, vomiting, fatigue, weakness, low blood pressure, and hormone changes. Buprenorphine can be misused and cause serious respiratory depression and death. It can also cause constipation, adrenal ins
How Buprenex works in the bodyBuprenorphine is an opioid that binds to the mu-opioid receptor in the body, but does not activate it as strongly as other opioids like heroin or oxycodone. This means that its effects do not increase significantly with larger doses, reducing the chance of overdose. Additionally, it does not cause the same level of sedation or euphoria as other opioids, which can help improve quality of life for those in severe pain. It is important to note that if taken by someone who is already dependent on opioids, buprenorphine can cause a rapid and intense onset of withdrawal symptoms. The prescription drug Subox
When to interrupt dosage
The suggested dosage of Buprenex hinges upon the diagnosed condition, such as Pain, Pain and Opioid Dependence. The measure of dosage changes dependent on the technique of administration (e.g. Tablet - Oral or Sublingual) presented in the table hereunder.Condition
Dosage
Administration
Pain
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Opioid-Related Disorders
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Pain
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Warnings
Buprenex has twenty-two contraindications and should not be combined with the conditions presented in the accompanying table.Buprenex ContraindicationsCondition
Risk Level
Notes
Alcohol Withdrawal Delirium
Do Not Combine
Asthma
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
suspected gastrointestinal obstruction
Do Not Combine
Pulse Frequency
Do Not Combine
Asthma
Do Not Combine
Gastrointestinal obstruction
Do Not Combine
Head
Do Not Combine
ethanol
Do Not Combine
Stomatitis
Do Not Combine
Abdomen
Do Not Combine
severe CNS depression
Do Not Combine
opioid naive
Do Not Combine
Myasthenia Gravis
Do Not Combine
Epilepsy
Do Not Combine
Hypocalcemia
Do Not Combine
Hypokalemia
Do Not Combine
Hypomagnesemia
Do Not Combine
Mental Depression
Do Not Combine
Cerebrospinal Fluid
Do Not Combine
Long QT Syndrome
Do Not Combine
Common Buprenex Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Buprenorphine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Buprenorphine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Buprenorphine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Buprenorphine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Buprenorphine.
Buprenex Toxicity & Overdose RiskSigns of an overdose on opioids include very small pupils, sleepiness, low blood pressure, and difficulty breathing, which can lead to death.
Buprenex Novel Uses: Which Conditions Have a Clinical Trial Featuring Buprenex?
21 active clinical trials are being conducted to examine the potential of Buprenex to alleviate Opioid Dependence, Pain and Discomfort.Condition
Clinical Trials
Trial Phases
Pain
0 Actively Recruiting
Pain
0 Actively Recruiting
Opioid-Related Disorders
0 Actively Recruiting
Buprenex Reviews: What are patients saying about Buprenex?
5Patient Review
5/7/2009 Though this medication appears to be alleviating my cat's pain, I have significant concerns about its long-term effects. I will be contacting the veterinarian for further guidance.
5Patient Review
5/4/20084.7Patient Review
11/5/2009 I've been using this as a replacement for opiates and it's working really well. I haven't had any withdrawal symptoms, which is amazing. I currently inject 2 vials 4-5 times a day for pain and it's much better than the feeling of taking opiates.
4.3Patient Review
10/6/2009 My cat had some puncture wounds that my vet said were most likely from a fight or jumping over a wire fence. They gave him this injection, but unfortunately he now has kidney failure.
4Patient Review
11/20/2010 Not my first choice, but better than I initially thought.
Patient Q&A Section about buprenex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of Buprenex?
"The following are rare but serious side effects of Buprenex: life-threatening respiratory depression, drowsiness, severe constipation, nausea, vertigo, and allergic reaction."
Answered by AI
What is Buprenex used for?
"The drug Buprenorphine is used to help relieve pain that is moderate to severe. It belongs to a class of drugs known as opioids, which are drugs that work by changing how the brain and body respond to pain."
Answered by AI
Is Buprenex the same as Suboxone?
"Buprenorphine and Suboxone are not the same thing; Suboxone is a two-ingredient drug used to treat opioid dependence, while buprenorphine is an opioid agonist that can be used to treat either opioid dependence or moderate-to-severe pain. However, Suboxone is not used to treat pain."
Answered by AI
Can humans take Buprenex?
"Buprenex is a generic medication that is typically safe for humans to use if appropriately prescribed and administered by a health care provider."
Answered by AI