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What is Lopressor Hct
MetoprololThe Generic name of this drug
Treatment SummaryMetoprolol is a type of medication used to reduce blood pressure. It comes in two forms, immediate-release and extended-release. The extended-release version is more widely used because it has lower levels of absorption into the bloodstream. Metoprolol has been widely prescribed in the US, Netherlands, and New Zealand since it was approved by the FDA in 1978. It is one of the most commonly used beta-blockers for treating high blood pressure.
Lopressoris the brand name
Lopressor Hct Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lopressor
Metoprolol
1978
983
Approved as Treatment by the FDA
Metoprolol, also known as Lopressor, is approved by the FDA for 4 uses including Hemodynamically Stable and Hypertensive disease .Hemodynamically Stable
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Hydrochlorothiazide
Hypertension
Used to treat nonresponsive to antihypertensive monotherapy in combination with Hydrochlorothiazide
Heart Attack
Effectiveness
How Lopressor Hct Affects PatientsMetoprolol is used to slow the heart rate, reduce cardiac excitability, and decrease the demand for oxygen in the heart. Studies have shown that taking metoprolol can reduce the risk of sudden cardiac death and heart attack. In clinical trials done in 1990, it was found that long-term use of metoprolol after a heart attack could reduce mortality and re-infarction rates by 17%.
How Lopressor Hct works in the bodyMetoprolol reduces the activity of certain receptors in the heart, slowing the heart rate and reducing the amount of blood flowing through the heart. This drug has no effect on other parts of the body, such as the nervous system.
When to interrupt dosage
The suggested portion of Lopressor Hct is contingent upon the identified condition, including Hemodynamically Stable, Thyroid Crisis and Atrial Fibrillation. The amount of dosage is specified, as per the method of delivery (e.g. Tablet, coated or Tablet - Oral) recorded in the table beneath.Condition
Dosage
Administration
Chest Pain
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Heart Attack
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Hypertension
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Migraine Disorders
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Atrial Fibrillation
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Thyroid Crisis
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Migraine
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Hypesthesia
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Hypesthesia
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Hemodynamically Stable
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Tachycardia, Supraventricular
, 50.0 mg, 100.0 mg, 5.0 mg/mL, 25.0 mg, 200.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/mL, 23.75 mg, 190.0 mg, 90.0 mg, 47.5 mg, 37.5 mg, 75.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intravenous, Kit, Solution - Intravenous, Solution, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Lopressor Hct ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Metoprolol may interact with Pulse Frequency
Heart Block
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Heart Decompensation
Do Not Combine
Pulse Frequency
Do Not Combine
severe bradycardia
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
Common Lopressor Hct Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Metoprolol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Metoprolol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Metoprolol.
Agrostis gigantea pollen
Major
The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Metoprolol.
Agrostis stolonifera pollen
Major
The risk of a hypersensitivity reaction to Agrostis stolonifera pollen is increased when it is combined with Metoprolol.
Lopressor Hct Toxicity & Overdose RiskThe highest toxic dose of metoprolol in rats is estimated to be between 3090 and 4670 milligrams per kilogram. Overdosing on metoprolol may cause a slow heartbeat, low blood pressure, difficulty breathing, and heart failure. In the event of an overdose, treatment involves emptying the stomach and then addressing the symptoms. There is no evidence to suggest that metoprolol causes cancer, genetic mutations, or infertility. If taken for a long period of time at high doses, it has been linked to small harmless lung tumors.
Lopressor Hct Novel Uses: Which Conditions Have a Clinical Trial Featuring Lopressor Hct?
319 active clinical trials are currently investigating the potential of Lopressor Hct to mitigate Hypesthesia, Thyroid Crisis and Hypertensive diseases.Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
95 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Migraine
52 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Hypertensive disease
22 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Hemodynamically Stable
0 Actively Recruiting
Tachycardia, Supraventricular
1 Actively Recruiting
Not Applicable
Chest Pain
2 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Hypesthesia
8 Actively Recruiting
Not Applicable, Phase 1
Hypertension
0 Actively Recruiting
Thyroid Crisis
0 Actively Recruiting
Heart Attack
27 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1
Hypesthesia
3 Actively Recruiting
Not Applicable
Migraine Disorders
1 Actively Recruiting
Phase 3
Lopressor Hct Reviews: What are patients saying about Lopressor Hct?
5Patient Review
11/16/2013 After Lupron treatment, I started having "heat flashes" or "sweat fits". However, this stopped happening about three years ago. Some have suggested that metoprolol tartrate may be the source of the problem.
5Patient Review
12/21/2013 I've been taking this medication for 15 years with no issues whatsoever.
5Patient Review
3/18/20094Patient Review
4/3/2010 I was really pleased with this medication. I'm sensitive to a lot of drugs, but this one didn't bother my stomach or leave me feeling irritated.
4Patient Review
6/17/2009Patient Q&A Section about lopressor hct
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does metoprolol have hydrochlorothiazide in it?
"For the extended-release tablets, the recommended starting dose for adults is one tablet containing 25 mg of metoprolol and 12.5 mg of hydrochlorothiazide once daily. Your doctor may adjust the dose as needed."
Answered by AI
Is Lopressor a water pill?
"Lopressor HCT is a combination of a beta-blocker and thiazide diuretic used to treat high blood pressure. Lopressor HCT is available in generic form."
Answered by AI
What is Lopressor HCT used for?
"Metoprolol is a beta-blocker that works by blocking the action of certain natural chemicals in your body (such as epinephrine) that affect the heart and blood vessels. This results in a decrease in heart rate and blood pressure. Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water.
This medication is for treating high blood pressure. It contains two medications, metoprolol and hydrochlorothiazide. Metoprolol is a beta-blocker that works by blocking the action of certain natural chemicals that affect the heart and blood vessels, which results in a decrease in heart rate and blood pressure. Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water."
Answered by AI
Is metoprolol tartrate the same as hydrochlorothiazide?
"Hydrochlorothiazide is a thiazide diuretic that helps to remove excess water from the body. Metoprolol is a beta-blocker that works to block the effects of adrenaline, helping to lower blood pressure. Together, these two medications are used to treat hypertension, or high blood pressure."
Answered by AI