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What is Toposar
EtoposideThe Generic name of this drug
Treatment SummaryEtoposide is a medication derived from the podophyllotoxin plant used to treat cancer. It works by forming a complex with DNA and topoisomerase II, which prevents the repair of DNA and blocks the entry into the mitotic phase of cell division, leading to cell death. Etoposide is most effective during the G2 and S phases of the cell cycle.
VePesidis the brand name
Toposar Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
VePesid
Etoposide
1983
31
Approved as Treatment by the FDA
Etoposide, also known as VePesid, is approved by the FDA for 4 uses which include Non-Small Cell Lung Cancer and Non-Small Cell Lung Carcinoma (NSCLC) .Non-Small Cell Lung Cancer
Used to treat Non-Small Cell Lung Carcinoma (NSCLC) in combination with null
Non-Small Cell Lung Carcinoma (NSCLC)
Used to treat Non-Small Cell Lung Carcinoma (NSCLC) in combination with null
Non-Hodgkin's Lymphoma (NHL)
Used to treat Non-Hodgkin's Lymphoma (NHL) in combination with null
Non-Hodgkin's Lymphoma
Used to treat Non-Hodgkin's Lymphoma (NHL) in combination with null
Effectiveness
How Toposar Affects PatientsEtoposide is a drug used to treat cancer. It stops cell growth by blocking DNA synthesis, and affects cells going through the S and G2 phases of the cell cycle. At high concentrations, it causes cells to die during mitosis. At lower concentrations, it prevents cells from entering prophase. Etoposide works by damaging DNA strands or creating free radicals.
How Toposar works in the bodyEtoposide works by damaging the DNA of cancer cells. It does this by blocking the enzyme that lets cells repair their DNA. This prevents cancer cells from dividing and reproducing, leading to their death. Etoposide is most effective on cells in certain stages of cell division, specifically the S and G2 phases. In addition to its anti-tumor effects, it can also have a carcinogenic effect when it blocks the beta isoform of the enzyme.
When to interrupt dosage
The measure of Toposar is contingent upon the distinguished illness, for example Gestational Trophoblastic Disease, recalcitrant Testicular cancer and Retinoblastoma. The dosage amount can be found in the table below, contingent upon the technique of delivery (e.g. Capsule - Oral or Capsule, liquid filled - Oral).Condition
Dosage
Administration
Retinoblastoma
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Testicular Neoplasms
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Sarcoma
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Carcinoma, Merkel Cell
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Neoplasms
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Advance Directives
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Sarcoma
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Ovarian Cancer
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Non-Small Cell Lung Cancer
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Thymus Neoplasms
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Multiple Myeloma
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Neuroblastoma
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Acute Myeloid Leukemia
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Non-Hodgkin's Lymphoma
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Acute Lymphoblastic Leukemia
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Sarcoma
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Small Cell Lung Cancer
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Gestational Trophoblastic Disease
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Prostate Cancer
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Hodgkin Disease
, 20.0 mg/mL, 50.0 mg, 100.0 mg, 50.0 mg/mL, 100.0 mg/mL, 150.0 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Liquid - Intravenous, Liquid, Oral, Capsule, Capsule - Oral, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, liquid filled, Capsule, liquid filled - Oral
Warnings
There are 20 known major drug interactions with Toposar.Common Toposar Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Etoposide is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Etoposide is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Etoposide is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Etoposide is combined with Acteoside.
Aldosterone
Major
The risk or severity of adverse effects can be increased when Etoposide is combined with Aldosterone.
Toposar Toxicity & Overdose RiskTaking too much of this drug may lead to hair loss, constipation, diarrhea, nausea and vomiting, and even cancer in some cases.
Toposar Novel Uses: Which Conditions Have a Clinical Trial Featuring Toposar?
There are 1617 active studies investigating the potential of Toposar to alleviate Neuroblastoma (NB), Merkel cell cancer and Non-Small Cell Lung Cancer.Condition
Clinical Trials
Trial Phases
Ovarian Cancer
16 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Acute Myeloid Leukemia
263 Actively Recruiting
Phase 2, Phase 1, Phase 3, Phase 4, Early Phase 1, Not Applicable
Small Cell Lung Cancer
45 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Early Phase 1
Sarcoma
51 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Advance Directives
0 Actively Recruiting
Neuroblastoma
0 Actively Recruiting
Retinoblastoma
4 Actively Recruiting
Phase 2, Not Applicable, Phase 1
Sarcoma
0 Actively Recruiting
Testicular Neoplasms
0 Actively Recruiting
Carcinoma, Merkel Cell
0 Actively Recruiting
Hodgkin Disease
0 Actively Recruiting
Gestational Trophoblastic Disease
1 Actively Recruiting
Phase 2
Multiple Myeloma
6 Actively Recruiting
Phase 2, Phase 1
Thymus Neoplasms
0 Actively Recruiting
Acute Lymphoblastic Leukemia
116 Actively Recruiting
Phase 1, Phase 3, Phase 2, Not Applicable, Early Phase 1, Phase 4
Prostate Cancer
60 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 1, Early Phase 1
Neoplasms
0 Actively Recruiting
Non-Small Cell Lung Cancer
314 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4, Early Phase 1
Sarcoma
0 Actively Recruiting
Non-Hodgkin's Lymphoma
125 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 3, Early Phase 1
Patient Q&A Section about toposar
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Toposar used for?
"Toposar is used to treat cancer of the lung or testicles. It is usually given in combination with other cancer medicines as part of a chemotherapy treatment."
Answered by AI
How do I give etoposide?
"Etoposide should not be given rapidly via intravenous injection, as this has been reported to cause hypotension as a possible side effect. Reactions may occur at the injection site during administration of etoposide."
Answered by AI
What is the use of fosaprepitant?
"Aprepitant and fosaprepitant injection are used to prevent nausea and vomiting in adults and children caused by certain cancer chemotherapy treatments."
Answered by AI
Is etoposide a chemotherapy drug?
"Etoposide is a cancer treatment drug, it can be given under the brand names Etopophos or Vepesid. It is used to treat various types of cancer."
Answered by AI