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Herbal Supplement

Milk Thistle in Body Dysmorphic Disorder

Phase 2
Waitlist Available
Led By Jon E Grant, JD, MD, MPH
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 9 weeks

Summary

This trial is testing milk thistle, a plant known for its health benefits, to see if it can help adults with body dysmorphic disorder. The study involves 15 participants who will receive milk thistle over several weeks. Researchers hope that milk thistle's antioxidant and anti-inflammatory properties will improve symptoms of this condition. Milk thistle, derived from the species Silybum marianum, is traditionally used as a hepatoprotective agent.

Eligible Conditions
  • Body Dysmorphic Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 9 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 9 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Yale Brown Obsessive Compulsive Scale Modified for Body Dysmorphic Disorder (BDD-YBOCS)
Secondary study objectives
Clinical Global Impression- Severity and Improvement (CGI)
Hamilton Anxiety Rating Scale (HAM-A)
Hamilton Depression Rating Scale (HAM-D)
+1 more

Side effects data

From 2022 Phase 2 trial • 55 Patients • NCT02337634
18%
Headache
6%
Reduced appetite
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo
Milk Thistle

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Silymarin (Milk Thistle)Experimental Treatment1 Intervention
Each subject will have a 4 week treatment phase with milk thistle.
Group II: PlaceboPlacebo Group1 Intervention
4 week placebo phase before or after milk thistle phase depending on randomization.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Milk Thistle
2015
Completed Phase 2
~80

Find a Location

Who is running the clinical trial?

University of ChicagoLead Sponsor
1,058 Previous Clinical Trials
765,596 Total Patients Enrolled
Jon E Grant, JD, MD, MPHPrincipal InvestigatorUniversity of Chicago
7 Previous Clinical Trials
889 Total Patients Enrolled
~0 spots leftby Dec 2025
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