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Herbal Supplement

Milk Thistle for Body Dysmorphic Disorder

Phase 2
Waitlist Available
Led By Jon E Grant, JD, MD, MPH
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 9 weeks
Awards & highlights

Study Summary

This trial will study the effects of milk thistle on 15 people, divided into two 4-week phases with a one-week break in between. One phase will have the participants taking milk thistle, and the other phase will have them taking a placebo. The trial will be double-blind, meaning neither the participants nor the researchers will know which group is taking the milk thistle until the trial is over.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 9 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 9 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Yale Brown Obsessive Compulsive Scale Modified for Body Dysmorphic Disorder (BDD-YBOCS)
Secondary outcome measures
Clinical Global Impression- Severity and Improvement (CGI)
Hamilton Anxiety Rating Scale (HAM-A)
Hamilton Depression Rating Scale (HAM-D)
+1 more

Side effects data

From 2020 Phase 2 trial • 22 Patients • NCT02473913
17%
Nausea
6%
Insomnia
6%
Bloating
6%
Headaches
100%
80%
60%
40%
20%
0%
Study treatment Arm
Milk Thistle
Placebo

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Silymarin (Milk Thistle)Experimental Treatment1 Intervention
Each subject will have a 4 week treatment phase with milk thistle.
Group II: PlaceboPlacebo Group1 Intervention
4 week placebo phase before or after milk thistle phase depending on randomization.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Milk Thistle
2015
Completed Phase 2
~70

Find a Location

Who is running the clinical trial?

University of ChicagoLead Sponsor
1,012 Previous Clinical Trials
734,070 Total Patients Enrolled
Jon E Grant, JD, MD, MPHPrincipal InvestigatorUniversity of Chicago
7 Previous Clinical Trials
877 Total Patients Enrolled
~0 spots leftby May 2025
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