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Ketamine for the Treatment of Opioid Use Disorder and Depression

Phase 2
Waitlist Available
Led By Jennifer Jones, MD
Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up actual time frame 23 months.

Summary

This trial tests if adding ketamine to buprenorphine treatment can better help people with both opioid addiction and depression. It targets those who may not respond well to typical treatments. Ketamine may quickly improve mood, while buprenorphine helps manage addiction.

Eligible Conditions
  • Opioid Use Disorder
  • Depression
  • Opioid Addiction

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~actual time frame 23 months.
This trial's timeline: 3 weeks for screening, Varies for treatment, and actual time frame 23 months. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Percentage of Individuals Completing Informed Consent
Percentage of Individuals Completing the Full Protocol
Secondary study objectives
Change in Depression Severity

Side effects data

From 2020 Phase 4 trial • 75 Patients • NCT03156504
1%
Lightheadedness with low blood pressure
1%
Pump Malfunction
1%
PTSD
100%
80%
60%
40%
20%
0%
Study treatment Arm
Ketamine

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Group A (Ketamine)Experimental Treatment1 Intervention
Group II: Group B (Placebo)Placebo Group1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ketamine Hydrochloride
2018
Completed Phase 4
~1900

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaLead Sponsor
977 Previous Clinical Trials
7,400,966 Total Patients Enrolled
National Institute on Drug Abuse (NIDA)NIH
2,595 Previous Clinical Trials
3,328,723 Total Patients Enrolled
Jennifer Jones, MDPrincipal Investigator - Medical University of South Carolina
Texas Health Harris Methodist Continued Care Hospital, Texas Health Harris Methodist Heart Center
Medical University Of South Carolina College Of Medicine (Medical School)
~4 spots leftby Dec 2025
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