← Back to Search

Almonds for Wrinkles

N/A
Recruiting
Led By Raja Sivamani, MD MS AP
Research Sponsored by Integrative Skin Science and Research
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Must not have
Has an autoimmune photosensitive condition or known genetic condition with a deficiency in collagen production (such as Ehler-Danlos)
Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 weeks

Summary

This trial examines how eating almonds affects skin health in women of different ages and skin tones.

Who is the study for?
This trial is for premenopausal and postmenopausal women aged 35-70, with a BMI of 18.5-35 kg/m2, who have maintained their diet and skincare routine for at least 1 month. It's not suitable for those with nut allergies, on oral collagen or vitamin E supplements, pregnant/breastfeeding women, recent facial procedure recipients, tobacco users, or individuals with certain skin diseases.
What is being tested?
The study examines if eating whole almonds affects the production of collagen in the skin and improves wrinkles and pigmentation among women of all Fitzpatrick skin types. Participants will be compared to those consuming a non-nut snack to see differences in skin health outcomes.
What are the potential side effects?
Since this trial involves food consumption (whole almonds), potential side effects may include digestive discomfort or allergic reactions for those sensitive to nuts. However, individuals with known nut allergies are excluded from participation.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have a condition that affects my skin's reaction to sunlight or causes weak collagen.
Select...
I currently smoke or have smoked more than 10 pack-years.
Select...
I have a skin condition on my face that could affect skin assessments.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Facial wrinkles
Skin collagen and elastin quantification
Secondary study objectives
Expression of enzymes that either degrade collagen (MMP1) or inhibit collagen degradation (TIMP1) on skin biopsies
Facial Wrinkles
Pigment intensity score
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: AlmondsExperimental Treatment1 Intervention
Consumption of almonds 5 times per week
Group II: Control SnackPlacebo Group1 Intervention
Consumption of protein and calorie matched non-nut-based food 5 times per week

Find a Location

Who is running the clinical trial?

Integrative Skin Science and ResearchLead Sponsor
32 Previous Clinical Trials
1,914 Total Patients Enrolled
1 Trials studying Pigmentation
90 Patients Enrolled for Pigmentation
Raja Sivamani, MD MS APPrincipal InvestigatorIntegrative Skin Science and Research
4 Previous Clinical Trials
138 Total Patients Enrolled
~28 spots leftby Jan 2026
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top