Blood-Flow Restriction Exercise for Knee Replacement

Recruiting in Palo Alto (17 mi)

Overseen BySteven Elmer

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Michigan Technological University

No Placebo Group

Trial Summary

What is the purpose of this trial?This study will determine the safety and efficacy of using blood-flow restriction exercise enhancement (B-FREE) to overcome persistent quadriceps muscle weakness that occurs following a total knee replacement (TKR).

Eligibility Criteria

This trial is for adults aged 40-75 who have had a knee replacement over 6 months ago and haven't had previous knee injuries or surgeries. It's not for those with diabetes, heart conditions, neurological disorders, certain implanted devices, uncontrolled high blood pressure, or smokers.

Inclusion Criteria

I have never had a knee injury or surgery.

I am between 40 and 75 years old.

Exclusion Criteria

I have had a heart attack or stroke.

I have high blood pressure that is not controlled by medication.

I have diabetes.

I have a heart or lung condition.

I have been diagnosed with a neurological disorder.

Participant Groups

The study tests the B-FREE method to see if it helps strengthen thigh muscles after total knee replacement surgery. Participants will use this exercise technique designed to improve muscle strength by restricting blood flow during exercise.

2Treatment groups

Experimental Treatment

Active Control

Group I: Adults with TKR Perform Home Exercise ProgramExperimental Treatment1 Intervention

Participants that have a total knee replacement will complete a home-based exercise program

Group II: Healthy Controls OnlyActive Control1 Intervention

Participants that have no history of knee joint dysfunction will serve as age-matched uninjured controls