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Diagnostic Test

De-resuscitation Informed by Ultrasound for Patients With Sepsis (DRI-US Trial)

N/A
Waitlist Available
Led By Keith Corl, MD
Research Sponsored by The Miriam Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 28 days and during hospital admission up to 24 weeks
Awards & highlights
No Placebo-Only Group

Summary

This trial tests if using a special ultrasound score to guide fluid removal helps critically ill sepsis patients more than usual care. Doctors use ultrasound to check for fluid buildup and decide on fluid removal based on the results. The goal is to see if this method reduces harmful fluid levels in these patients.

Eligible Conditions
  • Sepsis
  • Volume Overload

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~28 days and during hospital admission up to 24 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 28 days and during hospital admission up to 24 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Cumulative Fluid Balance at 5 days post ICU discharge or ICU Discharge
Secondary study objectives
28-day and in-hospital mortality
Change in SOFA score
Daily Sonographic B Line Measurement
+3 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: VExUS-Guided ArmExperimental Treatment1 Intervention
Will receive 24 hour fluid balance target based on daily VExUS score.
Group II: Usual Care Control ArmActive Control1 Intervention
Treating team will be blinded to results of daily VExUS score and will set 24 hour fluid balance target based on usual care.

Find a Location

Who is running the clinical trial?

The Miriam HospitalLead Sponsor
245 Previous Clinical Trials
37,746 Total Patients Enrolled
Keith Corl, MDPrincipal InvestigatorRhode Island Hospital / The Miriam Hospital
1 Previous Clinical Trials
113 Total Patients Enrolled
1 Trials studying Sepsis
113 Patients Enrolled for Sepsis
~33 spots leftby Dec 2025
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