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What is Combipatch
NorethisteroneThe Generic name of this drug
Treatment SummaryEstradiol is a hormone naturally produced in female bodies. It is used in hormone therapy to treat symptoms related to low estrogen levels, such as hot flashes and vaginal dryness. Estradiol is available as a pill, injection, vaginal ring, patch, spray, gel, or cream. It is also often used as a pro-drug ester, like Ethinyl Estradiol (EE), which is the estrogenic component of most combination birth control pills. EE is more bioavailable and more resistant to metabolism than regular estradiol, making it better suited for oral administration.
Neconis the brand name
Combipatch Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Necon
Norethisterone
1967
347
Effectiveness
How Combipatch Affects PatientsEstradiol is used to reduce hot flashes and other menopausal symptoms, as well as improve vaginal dryness and pain during sex. It also helps increase bone density and affects the levels of certain proteins in the liver. However, it can also cause an increased risk of cardiovascular disease, deep vein thrombosis, and stroke, so it is not recommended for patients at high risk of these conditions. Estrogen can also cause an increase in the body's ability to form blood clots, which is associated with taking oral contraceptives or being pregnant. It is believed that estrogen increases levels of sodium in the body, which is
How Combipatch works in the bodyEstrogen is a hormone found in many parts of the body, including the breasts, uterus, ovaries, skin, prostate, bones, and brain. In young women, the main source of estrogen is from the ovaries. After menopause, however, most of the estrogen produced in the body comes from the adrenal glands. Estrogen binds to two types of receptors in the body, ER-alpha and ER-beta. When estrogen binds to these receptors, it enters the target cell's nucleus and triggers gene transcription, which then produces proteins that cause estrogenic effects. These effects can include hot flashes, chills, vaginal
When to interrupt dosage
The suggested dosage of Combipatch is contingent upon the determined condition, for example, Premature Menopause, Pharmaceutical Preparations and Postmenopause. The measure of dosage shifts, in light of the administration technique laid out in the accompanying table.Condition
Dosage
Administration
Endometriosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Atrophic
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Low Testosterone
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Therapeutic procedure
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hot flashes
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
female castration
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Birth Control
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Fracture
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Osteoporosis, Postmenopausal
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Primary Ovarian Insufficiency
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Vasomotor System
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Oral Contraceptives
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hormonal Contraception
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Estrogen Deprivation Symptoms
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Menopause
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
hypoestrogenism
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Endometriosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Osteoporosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hormone Replacement Therapy
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Warnings
Combipatch ContraindicationsCondition
Risk Level
Notes
Liver Diseases
Do Not Combine
Thrombophilia
Do Not Combine
Vaginal Hemorrhage
Do Not Combine
Malignant Neoplasms
Do Not Combine
Benign hepatic neoplasm
Do Not Combine
Breast Cancer
Do Not Combine
Thromboembolism
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Norethisterone may interact with Pulse Frequency
Common Combipatch Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Norethisterone.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Norethisterone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Norethisterone.
Clomipramine
Major
The metabolism of Clomipramine can be increased when combined with Norethisterone.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Norethisterone.
Combipatch Toxicity & Overdose RiskAfter 90 days of testing, the highest safe dose of estradiol in rats was found to be 0.003 mg/kg per day. The lowest toxic dose of ethinyl estradiol is 21 mg/kg per day for women, with an LD50 of 960 mg/kg in rats. Symptoms of an overdose on estradiol may include nausea, vomiting, abdominal pain, breast tenderness, blood clots, and vaginal bleeding. If an overdose occurs, it is recommended to stop the treatment and offer supportive care.
Combipatch Novel Uses: Which Conditions Have a Clinical Trial Featuring Combipatch?
867 active clinical trials are currently evaluating the potential of Combipatch in providing relief from Osteoporosis, Polymenorrhea and Urogenital Atrophy.Condition
Clinical Trials
Trial Phases
Osteoporosis
32 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3
Endometriosis
34 Actively Recruiting
Early Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Phase 1
Atrophic
4 Actively Recruiting
Phase 4, Not Applicable
Birth Control
28 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Low Testosterone
6 Actively Recruiting
Phase 4, Phase 2, Phase 1
Endometriosis
3 Actively Recruiting
Phase 4, Not Applicable
Oral Contraceptives
2 Actively Recruiting
Not Applicable
Hot flashes
13 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Early Phase 1
Osteoporosis, Postmenopausal
0 Actively Recruiting
Estrogen Deprivation Symptoms
0 Actively Recruiting
female castration
0 Actively Recruiting
Hormone Replacement Therapy
0 Actively Recruiting
Hormonal Contraception
0 Actively Recruiting
hypoestrogenism
1 Actively Recruiting
Phase 4
Fracture
0 Actively Recruiting
Vasomotor System
0 Actively Recruiting
Primary Ovarian Insufficiency
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Menopause
0 Actively Recruiting
Combipatch Reviews: What are patients saying about Combipatch?
5Patient Review
11/28/2018 I've been using this treatment for 15 years to effectively manage hot flashes. I don't have any issues with the patches staying on, and they last me an entire week. The only downside is that they're quite expensive; however, given how well they work, I think they're worth the price.
5Patient Review
3/13/2019 I was pleased to find quick relief from hot flashes and irritability within a week of using this patch. I have noticed increased appetite and consequent weight gain; however, I am confident that I can manage this through diet changes. All in all, this is a great product!
5Patient Review
1/6/2020 I've been using this patch for 11 years and it's really helped me. I never took it at full strength because even one patch a week caused bloating and breast pain, so I tapered over the years. Now I'm down to half a patch every 10 days, and I tried tapering to zero last year but my hot flashes returned after 3-4 weeks. Hopefully I can continue tapering successfully over the next few years.
5Patient Review
6/27/2021 I've been using this product for over 20 years without any issues. I just found out that Medicare won't cover it anymore, which is a bummer because it's really helped me maintain my quality of life.
5Patient Review
2/10/2022 I started seeing results from this patch within two weeks of starting it, and now three years post-menopause, I haven't had a hot flash since. If you're on the fence about trying it, just go for it!
5Patient Review
2/10/2022 I had some spotting during weeks three and five, but it wasn't too bad.
4.7Patient Review
1/20/2021 I've used combipatch for over a year and it's been great in regards to managing my menopausal symptoms. However, the most recent batch I received is definitely different; the disk is more rigid as opposed to pliable like before. Additionally, I'm now experiencing pretty significant irritation from this new patch but had no issue with the prior patches. Trying to tough it out but its very uncomfortable. Wondering why
4.7Patient Review
6/21/2022 I've been really happy with this patch overall, but the itching is a serious problem. I often end up scratching my skin raw because of it. Please improve the adhesive! Thank you for your time.
4.3Patient Review
7/18/2018 I was given this to help with hot flashes, mood changes, irritability etc. and it's been working great so far! I would recommend applying the patch immediately after bathing when skin is clean and dry. Otherwise, use alcohol to swab the area clean and make sure it's completely dry before applying the patch.
4.3Patient Review
4/28/2021 I had great results with this treatment until the manufacturer changed the adhesive. Now, I'm having terrible reactions, as are others who have discovered the same thing. We're all experiencing extreme itching, burning, dried red skin, and the patch falls off before it's time to change it out. This new adhesive is really causing problems for a lot of people. PLEASE go back to using the original adhesive!
4Patient Review
5/25/2022 I really love this patch! It's helped me a lot. However, the adhesive is very itchy on my skin. I've tried putting it on different parts of my body, but it always ends up being itchy and red. Please change the adhesive!
4Patient Review
11/22/2021 I was on this for a couple years and it really improved my quality of life by preventing hot flashes and night sweats. However, I stopped using it recently because the adhesive they switched to was incredibly itchy and caused redness that would last for days after taking the patch off.
3.7Patient Review
11/4/2019 I've been using this patch for almost nine months now. It's effectively stopped hot flashes, night sweats, and moodiness; however, I have experienced irregular spotting that lasts a few days each month. My doctor suggested trying half a patch; hopefully, this will work.
3.7Patient Review
11/16/2021 I've found that this treatment really helps with hot flashes. I was having them every 15 minutes prior to using the patch, but now they're much more manageable. However, I have noticed that the patch does come off easily if you sweat or shower, so I put a sterile transparent film over it to keep it in place. This has saved me a lot of money and hassle.
Patient Q&A Section about combipatch
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the CombiPatch used for?
"This medication is taken by women to help reduce menopause symptoms such as hot flashes and vaginal dryness. These symptoms are caused by the body producing less estrogen. The progestin in this medication helps lower the risk of cancer of the uterus, which can be caused by using estrogen."
Answered by AI
What is equivalent to CombiPatch?
"As of August 10th, 2022, there is no therapeutically equivalent version of CombiPatch available in the United States. It is important to note that there are many fraudulent online pharmacies that may try to sell an illegal generic version of CombiPatch. These medications can be counterfeit and potentially unsafe."
Answered by AI
Does CombiPatch make you gain weight?
"The use of progestin in addition to other treatments helps to prevent cancer of the uterus. It is important to discuss treatment options with a doctor to see what is best based on individual needs. There is no evidence to suggest that hormone therapy causes weight gain."
Answered by AI
How long does it take for CombiPatch to start working?
"COMBIPATCH is an effective combination hormone therapy that results in estrogen levels in your blood similar to what you would see in the early phase of your usual menstrual cycle during your premenopausal years. These levels are achieved within 12 to 24 hours after applying COMBIPATCH."
Answered by AI