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Monoclonal Antibodies

Zilovertamab vedotin for Non-Small Cell Lung Cancer

Phase 2
Waitlist Available
Research Sponsored by VelosBio Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to ~30 months
Awards & highlights

Study Summary

This trial is testing a new drug for six different types of cancer. The objective is to see if it is effective against cancer, and if it is safe.

Eligible Conditions
  • Non-Small Cell Lung Cancer
  • Breast Cancer
  • Stomach Cancer
  • Ovarian Cancer
  • Pancreatic Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to ~30 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to ~30 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Secondary outcome measures
AUC of MMAE
AUC of total antibody
Area under the plasma concentration-time curve (AUC) of zilovertamab vedotin
+11 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Zilovertamab vedotinExperimental Treatment1 Intervention
Participants will receive zilovertamab vedotin at 2.0 mg/kg given intravenously on Day 1 and Day 8 of repeated 21-day cycles. Treatment will continue until progressive disease or discontinuation.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Zilovertamab vedotin
2019
Completed Phase 2
~200

Find a Location

Who is running the clinical trial?

VelosBio Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)Lead Sponsor
1 Previous Clinical Trials
91 Total Patients Enrolled
VelosBio Inc.Lead Sponsor
1 Previous Clinical Trials
91 Total Patients Enrolled
Langdon L Miller, MDStudy DirectorVelosBio Inc.
1 Previous Clinical Trials
91 Total Patients Enrolled
~22 spots leftby Jun 2025
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