Low Dose Whole Lung Radiation Therapy for Patients With COVID-19 and Respiratory Compromise (VENTED Trial)
Palo Alto (17 mi)Overseen byArnab Chakravarti
Age: 18+
Sex: Any
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: Phase 2
Recruiting
Sponsor: Ohio State University Comprehensive Cancer Center
No Placebo Group
Prior Safety Data
Approved in 6 jurisdictions
Trial Summary
What is the purpose of this trial?Low doses of radiation in the form of chest X-rays have been used to treat people with pneumonia. This treatment was found to be effective by reducing inflammation and with minimal side effects. However, it was an expensive treatment and was eventually replaced with less costly treatments such as antibiotics. Radiation has also been shown in some animal experiments to reduce some types of inflammation.
Some patients diagnosed with COVID-19 pneumonia will experience worsening disease, which can become very serious, requiring the use of a ventilator. This is caused by inflammation in the lung from the virus and the immune system. For this study, the x-ray given is called radiation therapy. Radiation therapy uses high-energy X-ray beams from a large machine to target the lungs and reduce inflammation. Usually, it is given at much higher doses to treat cancers.
The purpose of this study is to find out if adding a single treatment of low-dose x-rays to the lungs might reduce the amount of inflammation in the lungs from a COVID-19 infection, which could help a patient to breathe without use of a ventilator.
Eligibility Criteria
Treatment Details
1Treatment groups
Experimental Treatment
Group I: Radiation ArmExperimental Treatment1 Intervention
Each subject will receive a dose of whole lung radiation. A second optional dose of 80 cGy may be delivered if no improvement after 3-10 days.
Radiation therapy is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
🇪🇺 Approved in European Union as Radiotherapy for:
- Breast cancer
- Lung cancer
- Colorectal cancer
- Prostate cancer
- Brain tumors
- Skin cancer
🇺🇸 Approved in United States as Radiation therapy for:
- Breast cancer
- Lung cancer
- Colorectal cancer
- Prostate cancer
- Brain tumors
- Skin cancer
- Cervical cancer
- Uterine cancer
🇨🇦 Approved in Canada as Radiotherapy for:
- Breast cancer
- Lung cancer
- Colorectal cancer
- Prostate cancer
- Brain tumors
- Skin cancer
🇯🇵 Approved in Japan as Radiation therapy for:
- Breast cancer
- Lung cancer
- Colorectal cancer
- Prostate cancer
- Brain tumors
- Skin cancer
- Esophageal cancer
🇨🇳 Approved in China as Radiotherapy for:
- Breast cancer
- Lung cancer
- Colorectal cancer
- Prostate cancer
- Brain tumors
- Skin cancer
- Nasopharyngeal cancer
🇨🇭 Approved in Switzerland as Radiation therapy for:
- Breast cancer
- Lung cancer
- Colorectal cancer
- Prostate cancer
- Brain tumors
- Skin cancer
Find a clinic near you
Research locations nearbySelect from list below to view details:
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical CenterColumbus, OH
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Who is running the clinical trial?
Ohio State University Comprehensive Cancer CenterLead Sponsor